``danger signals´´ and peripheral regulation play central roles in the development and control of organ sp
Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells ... upregulated in the FLSs of RA patients, and is enhanced days after GM-CSF treatment [7] In the present experiments, we assessed the dose and time kinetics of the effects of GM-CSF on MLN51 expression in ... transcriptional control, probably by blocking of the proteasome degradation pathway GM-CSF-induced MLN51 is involved in the hyperproliferation and anti-apoptosis of MH7A cells via the upregulation of FLIP...
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Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis pdf
... initiating the release of cytochrome c from mitochondria into the cytosol and increasing the activities of caspase and caspase 7, resulting in apoptosis of mouse RAW264.7 macrophages [30] Other ... protein, and was the first human protein shown to be indispensable for autophagy [44] The interaction between Beclin and its binding partners regulates the initial steps of autophagy Beclin also ... Inhibition of Hsp90b suppressed the CpG-B ODN-induced association of Hsp90b with Bcl-2, and impaired the inhibitory effect on the release of cytochrome c as well as the activation of caspase [31] These...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx
... was increased in both ERE1 and ERE2 in the presence of E2 Interestingly, the kinetics of E2-dependent binding of ERa and ERb to both ERE1 and ERE2 are different The binding of ERa is very low in ... observed in any of the EREs, irrespective of the absence and presence of E2 Binding of ERa and ERb was increased in both ERE1 and ERE2 of the HOXC13 promoter (Fig 5A, lanes 1–4) The levels of E2-induced ... of E2, and this binding was increased in the presence of E2 (Fig 5A,B; compare h and 6–8 h time points) These differences in the kinetic profiles of binding of ERa and ERb suggest that they have...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... unusual in having two histidine residues (rather than the His-Asn pair seen in OYE, MR and some of the other member proteins; Fig 1B) in the active site for ligand and substrate binding For those ... productive binding of steroid substrates: in the first, a (small) sub population of enzyme binds directly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactive ... 1A) and 2-cyclohexen-1-one indicate that these ligands bind above the si face of the FMN isoalloxazine ring and are held in position by hydrogen bond interactions with His181 and His184 [2] These...
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Báo cáo khoa học: Structural and functional roles for b-strand 7 in the a-crystallin domain of p26, a polydisperse small heat shock protein from Artemia franciscana pdf
... contact of b-strand 10 from the C-terminal extensions of monomers A and D with b-strands and in the a-crystallin domain of monomers C and B, respectively (Fig 8) A more prominent dimer–dimer interface ... domain The interface between monomers of a dimer involves interaction between strands b2 and b6 of neighboring monomers The p26 modifications examined in this study are not located in either of these ... [17,41,43–46] a-crystallin domain of p26 The p26 a-crystallin domain is similar in sequence to this region in other sHSPs, including wheat Hsp16.9; the protein confers thermotolerance on transformed...
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Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot
... acetyl-transferase-catalyzing inner domain E3BP domains: L3, N-terminal lipoyl domain; B, E3 binding domain; I, inner domain which associates with the inner domain of E2 Dotted connections indicate binding interactions ... E2 and E3 are included in Fig Apart from E2, the three domain E3-binding protein (E3BP, Fig 1) also has an anchoring C-terminal domain, an E3-binding domain and a mobile lipoyl domain Again, the ... running in opposite directions The monomer association involves the ATP-using C-terminal domains interacting near the base of that side of the wedge outside; the N-terminal domains form the outside...
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Báo cáo sinh học: "Shipping blood to a central laboratory in multicenter clinical trials: effect of ambient temperature on specimen temperature, and effects of temperature on mononuclear cell yield, viability and immunologic function" potx
... = the proportion of cells that are apoptotic or necrotic (as defined by Annexin V and 7AAD staining); i = the storage conditions of the whole blood specimen; and c = the storage condition of the ... C) The effects of extreme high ambient temperatures on maintaining internal temperatures within the range of 15-35°C was tested on the newly designed JVI shipping container The shipping container ... immediate and delayed processing of specimens were influenced not only by the delay in processing but also by the method of processing and by the type of anticoagulant used [27] Thus, although there...
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The chemical components of detergents and their roles in the washing process
... fabrics and on the washing machine’s heating elements - stabilise alkalinity at the correct level throughout the washing process thus giving good soil removal and enabling the other components of the ... necessarily involves the inclusion of a number of complex, new chemicals and a complete restructuring on the detergent's formula, often with significant increase in other existing ingredients For each of ... properties Phosphates help break up large particles of dirt into smaller ones, which can be washed out, and they help prevent fine dirt particles from combining and thus keep them in suspension in the...
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Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington’s disease pps
... to food and water ad libitum Both the housing and experimental use of animals followed the National Institutes of Health guidelines and were approved by the Institutional Animal Care and Use ... blocking buffer Protein loading was normalized using b-tubulin immunoblotting as a loading control Chemiluminescent detection of HRP (SuperSignal West Pico; Pierce) was followed by exposure of the ... cerebral cortex and striatum, respectively (**P < 0.01 and ***P < 0.001 relative to corresponding saline group) Note the reduction in the percentage ratio of GLT1/b-tubulin expression in cerebral...
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Báo cáo y học: " The Beijing genotype and drug resistant tuberculosis in the Aral Sea region of Central Asia" pot
... strains and spread more rapidly [34] Therefore, in the former Soviet Union, the introduction of Beijing strains may have coincided with the deterioration of socio-economic conditions and the ... of the Beijing genotype In the majority of cases identified, the fingerprint pattern typical for the Beijing genotype was weak compared to the other pattern, indicating that an exogenous re-infection ... http://respiratory-research.com/content/6/1/134 Figure IS6110 DNA fingerprint and spoligotype patterns of the 382 strains analysed IS6110 DNA fingerprint and spoligotype patterns of the 382 strains...
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Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx
... [7,15] Any injury to the exoskeleton of the crab immediately jeopardizes the integrity of the internal milieu of the organism Not only is there a real threat of loss of internal contents of the crab ... terminus of peptides and proteins In the case of fibrin, removal of carboxyl-terminal lysine residues renders the fibrin less sensitive to lysis by decreasing the ability of plasminogen and tissue-type ... to the amino-terminus of its extracellular domain Thrombin cleaves the amino-terminus of the PAR, allowing the internal ligand to autoactivate the receptor There are four known PARs in human...
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CHARACTERISATION OF GLUTAMYL TRANSPEPTIDASE AND ELUCIDATING ITS ROLES IN THE PATHOGENESIS OF HELICOBACTER PYLORI
... Cloning of ggt gene (full length and individual large and small subunits) from H pylori and expressing the recombinant proteins in E coli Raising and characterizing specific polyclonal and ... capable of provoking an immune response in the host In conclusion, this study has demonstrated the capability of GGT in generating H2O2, activating NF-κB and upregulating IL-8 in host cells Furthermore, ... hypothesis Interestingly, nuclear localization of GGT coincided with a decrease in the levels of glutathione in the nucleus, indicative of a role of GGT in causing redox imbalance in host cells...
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60733 roles in the family idioms and conversation
... for each other The sins of the father shall be visited upon the son You have to accept the family that you have.A close knit familyTo become independent from your mother.a match made in heavenChildren ... made in heaven? Who’s the black sheep in your family? Who’s the apple of your father’s eye? Are you a chip off the old block? Do any of your family members fight like cat and dog? Is blood thicker ... you left home? The Battle of the Sexes Look at the two adverts • Who are they targeted at? • What message are they trying to convey? • Is it wrong for women to embrace their masculine side or for...
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Analysis and control of nonlinear process systems
... areas of control engineering In the process industries there is a fair amount of non-linear model information and the task is to find ways to exploit this knowledge base On the other hand the analysis ... students specializing in control engineering or in applied mathematics Therefore these books not meet the needs of process engineering students interested in the application of these methods for ... (1999) L2-Gain and Passivity Techniques in Nonlinear Control (Communication and Control Engineering Series), Springer The above textbooks intend to cover a range of nonlinear analysis and control...
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Tài liệu AUTOMATIC MONITORING AND CONTROL OF COOLING WATER TREAMENT PRODUCTS docx
... substantial swings in the cycles obtained, from 3.5 to 16, in the system during the course of the study The sensor control unit, however, maintained the level of chemical inhibitor within set control ... conductivity “defeating” the existing makeup proportional inhibitor control and feed system The “beta” sensor and chemical inhibitor feed controller were installed at the plant in April, 2007 The city supplied ... ProChemTech to devise and commercialize an on-line spectrophotometer based monitor and controller to control feed of traced inhibitors After review of the technology in the hand held spectrophotometers...
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Tài liệu Stability and Control of Large-Scale Dynamical Systems pptx
... system (2.64) and (2.65) with respect to xI uniformly in xII0 The remainder of the proof involves similar arguments as given above and as in the proof of parts ii) v) of Theorem 2.3 and, hence, ... interior, and the closure of the set S by S, S, and S, respectively We write ã for the Euclidean vector norm, R(A) and N (A) for the range space and the null space of a matrix A, respectively, spec(A) ... viewed as an interconnection of interacting subsystems modeled by tearing, zooming, and linking In light of the fact that energy ow modeling arises naturally in largescale dynamical systems and vector...
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Tài liệu supervised tactical mobility behavior modeling and control of multi agent robotic vehicles doc
... in s p hi fo pt de in s p hi fo pt de in s p hi fo pt de in s p hi fo pt de in s p hi fo pt de in s p hi fo pt de in s p hi fo pt de in s p hi fo pt de in s p hi fo pt...
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Tài liệu CONSUMER PREFERENCE AND CONSUMPTION OF ORGANIC PRODUCTS IN THE EASTERN CAPE PROVINCE OF SOUTH AFRICA docx
... are marked increases in the future demand of all organic products This augurs well for the growth of the organic industry in the Eastern Cape and in South Africa in general The findings of this ... maintain its identity in the face of others, and therefore creates a feeling of "belonging" (Buruiana 2003) 17 10 Factors affecting the consumer awareness of organic products The results of the ... consumption of organics will go a long way in influencing the target market and marketing approach to drive the demand of organics The second LDF identified the person responsible for shopping and the location...
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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
... Disease Control and Prevention The role of BCG vaccine in the prevention and control of tuberculosis in the United States: a joint statement by the Advisory Council for the Elimination of Tuberculosis ... resurgence in the incidence of TB occurred in the United States and included increases in the number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving ... vaccination These developments have prompted a re-evaluation of the role of BCG vaccination in the prevention and control of TB in the United States CDC, the Advisory Council for the Elimination...
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